عدد المساهمات : 161
تاريخ التسجيل : 15/01/2013
العمر : 22
الموقع : hgulg vhpm
|موضوع: التركيبات الصيدلانية الجمعة يناير 03, 2014 9:05 am|| |
Pluroniclethicinorganogel – used to deliver NSAIDS, narcotics, and other drugs through the skin when other routes of administration are not viable.
Non-irritating to the skin, absorbs quickly and is practically odorless
Allows for maximal drug solubility and delivery of the drug through the skin microemulsion-based gel.
The active ingredient is incorporated into the appropriate phase.
The advantage that the current PLO gel offers is in its constituents that combine the desired properties of several entities to allow for maximal solubilization of drugs and maximal delivery of the drug through the skin.
Current PLO gels contain lecithin as a constituent. The strategy involved is that lecithin is thought to disorganize the structure of skin while still leaving it intact and unharmed. Its presence also increases the drug's solubility in the solvents. Lecithin, along with the pluronic constituent, act as surface-active agents to aid in the extraction of lipids from the stratum corneum. This is important because the stratum corneum acts as the principle barrier to the percutaneous penetration and subsequent absorption of topically applied drugs.
Water in the PLO gel acts as a penetration enhancer as well.
Can range from very thick to light syrupy and may have the appearance of a cream. It adheres well to the skin and rubs in easily.